Human Stem Cell Research Oversight (hSCRO) review/approval is required for ALL embryonic stem cell research and certain types of non-embryonic stem cell research, and is in addition to other required University of Pittsburgh research approvals, such as through Animal Research Protection, Institutional Review Board, or Institutional Biosafety.
hSCRO review ensures compliance with all federal and Commonwealth of Pennsylvania regulations governing the conduct of human embryonic stem cell research.
As there may be potential ethical concern with any pluripotent stem cell research, the hSCRO Committee's purview includes oversight of both embryonic and certain types of non-embryonic stem cell research.
The hSCRO Committee reviews research in accordance with:
- National Academies' Guidelines for Human Embryonic Stem Cell Research
- NIH Guidelines for Human Stem Cell Research
- hSCRO Policies and Procedures
- Human Stem Cell Research CITI Module
- and other relevant University of Pittsburgh research policies
Human Stem Cell Research Requiring Review/Approval by the hSCRO Committee
hSCRO review/approval is required for ALL embryonic stem cell research and certain types of non-embryonic stem cell research, and is in addition to other required University research approvals, such as IACUC, IRB or IBC.
Types of Non-embryonic Stem Cell Research Reviewed by hSCRO
- A clinical trial (human subjects) where the administration of fetal or embryonic stem cells is considered to be experimental and not standard of care.
- Transplantation of any type of human stem cell into an animal
- Transplantation of cells that originated from human iPS cells or cells/cell lines that were derived from human embryonic cells (ES)
Why Does hSCRO Review Non-embryonic Stem Cell Research?
As there may be potential ethical concerns with any pluripotent stem cells research, the hSCRO Committee's purview includes oversight of both embryonice and certain types of non-embryonic stem cell research. The Committee's specialized expertise and knowledge of the broad scope of human stem cell research being conducted at the University of Pittsburgh allows the hSCRO Committee to serve as a valuable resource.
How do I submit an application for review? How are hSCRO applications reviewed?
The investigator must complete an hSCRO application, and forward the application to firstname.lastname@example.org for review. There are two levels of hSCRO review: Administrative Review by the hSCRO Chair (Registration) and hSCRO Committee Review. The type of review required depends upon the nature of the research described in the application. Researchers may refer to review descriptions in the hSCRO application or contact the office for assistance if needed.